Asymmetric Mannich reaction of aromatic imines with malonates in the presence of multifunctional catalysts.

Kadri Kriis, Harry Martõnov, Annette Miller, Mia Peterson, Ivar Järving, Tõnis Kanger

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Article in Beilstein journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Kadri KriisDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.ORCID https://orcid.org/0000-0002-2503-7788

Harry MartõnovDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.ORCID https://orcid.org/0000-0003-2196-2658

Annette MillerDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.ORCID https://orcid.org/0000-0002-5014-6839

Mia PetersonDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.ORCID https://orcid.org/0009-0005-5866-9115

Ivar JärvingDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.ORCID https://orcid.org/0000-0001-6047-4759

Tõnis KangerDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.ORCID https://orcid.org/0000-0001-5339-9682

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various multifunctional enantiomerically pure organocatalysts were synthesized and screened in asymmetric Mannich reaction. The reaction of aromatic imines with malonates in the presence of amino acid-derived catalysts gave Mannich adducts in very high enantiomeric purities (up to 98% ee). It is proposed that a network of hydrogen and halogen bonds with Lewis bases, together with the steric effect of the

Indexed as

aromatic imineasymmetric catalysisMannich reactionnoncovalent interactionsorganocatalysis

Identifiers

PMID41568340

DOI10.3762/bjoc.22.8

PMCPMC12816990

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