ArticleAdvances in radiation oncology2026
Overall Survival in Men 80 and Older With Intermediate-Risk Prostate Cancer Who are Treated With Dose-Escalated Radiation and Androgen Deprivation Therapy Versus Dose-Escalated Radiation Alone: A National Cancer Database Analysis.
Article in Advances in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Purpose: Men 80 and over are not well represented on randomized clinical trials, including the studies that examined the addition of androgen deprivation (ADT) to radiation therapy (RT). However, octogenarians may be a group particularly susceptible to the side effects of ADT due to the rapid increase in age-related changes as one enters their 9th decade. We hypothesized that ADT, when added to RT in octogenarians with intermediate-risk prostate cancer, might be associated with worse overall survival, and that this effect would not hold for their younger counterparts. Methods and Materials: The National Cancer Database (NCDB) was queried for men ≥60 years old who received dose-escalated RT (EQD2 Results: There were 10,168 men who received RT + ADT versus 12,396 who received RT alone. In the RT + ADT group, a larger percentage of men had Gleason 4+3 disease (43% vs 26%, Conclusions: In this NCDB analysis, the addition of ADT to dose-escalated radiation in men between the ages of 60 and 70 with intermediate-risk prostate cancer showed improved overall survival. However, adding ADT to dose escalation in those 80 and older did not demonstrate an overall survival benefit.
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