ArticleFrontiers in psychiatry2025
Adaptive mentalization-based integrative therapy for severe personality disorder and mental illness: study protocol for a controlled longitudinal cohort study.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Personality Disorders that meet the criteria for a Severe Mental Illness (SMI-PD) tend to coincide with a greatly reduced quality of life and a lower life expectancy. Despite the numerous and complex needs of patients with SMI-PD, effective treatments for this group have not yet been established. Traditional treatments often fail to address the multitude of problems patients with SMI-PD struggle with and there is limited understanding about the treatment needs and effects. SMI-PD is associated with high economic costs to both the individual and society. Adaptive Mentalization-based Integrative Therapy (AMBIT) is a mentalization-based systematic approach designed to support teams in their care for people with multiple needs who distrust help. This study will investigate the effectiveness and cost-effectiveness of AMBIT in treating patients with SMI-PD. Methods: Patients aged 18 or older with SMI-PD receiving care at GGZ Rivierduinen and GGZ Altrecht ( Discussion: Little is known about the treatment needs of patients with SMI-PD and the effectiveness and cost-effectiveness of an AMBIT approach on this group of patients. The results of the present study will therefore contribute to the development of more tailored and effective psychological treatment for this complex group of patients. Trial Registration: Research Portal of CCMO Onderzoek met mensen, Trial Registration Number NL-010303, https://www.onderzoekmetmensen.nl/en/trial/57877, registered on June 27, 2025. OSF Registries, https://doi.org/10.17605/OSF.IO/QHYCW, preregistered on May 7, 2025.
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