Evidence map›Paper›PMID 41568238›Full record

ArticleAmerican heart journal plus : cardiology research and practice2026

Symptom phenotypes and coronary microvascular function in non-obstructive coronary artery disease: Insights beyond epicardial ischemia.

Kotaro Matsumoto, Kenichiro Otsuka, Shunsuke Kagawa, Hiroki Yamaura, Tsubasa Miura, Kazuya Sugioka, Wataru Saitoh, Akihiro Okamoto, Go Kajio, Naoki Fujisawa and 7 more

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In one paragraph

Article in American heart journal plus : cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kotaro MatsumotoDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Kenichiro OtsukaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Shunsuke KagawaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Hiroki YamauraDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Tsubasa MiuraMedical Device Division, Osaka Metropolitan University of Hospital, Osaka, 545-8585, Japan.
Kazuya SugiokaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Wataru SaitohDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Akihiro OkamotoDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Go KajioDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Naoki FujisawaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Tomohiro YamaguchiDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Takenobu ShimadaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Yusuke HayashiDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Atsushi ShibataDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Asahiro ItoDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Takanori YamazakiDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.
Daiju FukudaDepartment of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahicho, Abenoku, Osaka, 545-8585, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Study objective: To examine the relationship between coronary microvascular dysfunction (CMD) indices and chest pain presentation in patients with non-obstructive coronary artery disease (NOCA). Design and setting: Retrospective, single-center observational study. Participants: Patients with angiographically intermediate left anterior descending artery (LAD) stenosis and preserved epicardial physiology (fraction flow reserve, FFR >0.80), with no significant stenosis in vessels other than the LAD. Interventions: Invasive CMD assessment using coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and myocardial resistance reserve (MRR). Main outcome measures: Associations between symptom phenotypes and physiological indices, and the diagnostic performance of symptom-based assessment for detecting CMD. Results: Among 59 patients (mean age 69.2 years; 71 % male), CFR and MRR differed significantly across symptom phenotypes (both Conclusion: In patients with NOCA, coronary microvascular vasodilatory reserve varies according to symptom phenotype, highlighting the limited reliability of symptom assessment alone and underscoring the importance of objective physiological evaluation for characterizing CMD.

Indexed as

AnginaCoronary flow reserveCoronary microvascular dysfunctionMyocardial resistance reserveNonobstructive coronary artery disease

Identifiers

PMID41568238
PMCPMC12818273

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.