ArticleRSC advances2026
Natural-based catalysts for 5-hydroxymethylfurfural production from cane syrup for pharmaceutical applications.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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5 authors.
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Abstract
In this study, naturally derived carboxylic acids, including citric, malic, acetic, and lactic acids, were investigated as novel non-toxic catalysts for producing pharmaceutical-grade 5-HMF from cane syrup, thereby demonstrating a safer and more sustainable alternative to conventional synthesis routes. A continuous catalytic biphasic microreactor system was employed with dimethyl carbonate as an environmentally benign extraction solvent. Among the acids tested, citric acid exhibited the highest catalytic performance and was selected for further systematic optimization. Response surface methodology was utilized to identify and optimize key reaction parameters, including reaction temperature, residence time, organic-to-aqueous (O : A) volumetric ratio, initial syrup concentration, and catalyst loading. Optimal conditions were established as a reaction temperature of 180 °C, a residence time of 60 min, an O : A ratio of 0.5 : 1, an initial syrup concentration of 6.25 g L
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