ArticleRSC advances2026
Rongalite-mediated sequential homologative fluorination of oxindoles en route to 3-(fluoromethyl)-3-methylindolin-2-ones.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A rongalite-mediated, transition-metal-free reductive homologative-fluorination strategy has been developed for the synthesis of 3-(fluoromethyl)-3-methylindolin-2-ones. This methodology involves the monofluoromethylation of indolin-2-one derivatives, employing rongalite as a C1-homologating reagent, and diethylaminosulfur trifluoride (DAST) as the fluorine source. The reaction proceeds under mild conditions, offering excellent yields, high selectivity, and broad functional group tolerance on oxindoles. Overall, this approach provides a practical and sustainable route for CH
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