ArticleRSC advances2026
Harnessing Frémy's salt for tyrosine-directed bioconjugations.
Zachary V Samuels, Ava Stoddard, Wei-Siang Mark Kao, Mike A Cornejo, Emilia Strugala, Shane A McGlone, Lauren Furer, Cindy Rodriguez, Brian M Zeglis
Abstract read
In one paragraphArticle in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Ava StoddardDepartment of Chemistry, Hunter College, City University of New York New York NY 10065 USA bz102@hunter.cuny.edu.
Wei-Siang Mark KaoDepartment of Chemistry, Hunter College, City University of New York New York NY 10065 USA bz102@hunter.cuny.edu.
Mike A CornejoDepartment of Chemistry, Hunter College, City University of New York New York NY 10065 USA bz102@hunter.cuny.edu.
Emilia StrugalaDepartment of Chemistry, Hunter College, City University of New York New York NY 10065 USA bz102@hunter.cuny.edu.
Shane A McGloneDepartment of Chemistry, Hunter College, City University of New York New York NY 10065 USA bz102@hunter.cuny.edu.
Lauren FurerDepartment of Chemistry, Hunter College, City University of New York New York NY 10065 USA bz102@hunter.cuny.edu.
Cindy RodriguezDepartment of Chemistry, Hunter College, City University of New York New York NY 10065 USA bz102@hunter.cuny.edu.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MNovel Transgenic Mouse Models Addressing Outstanding Translational Barriers in Antibody-Based TherapeuticsR01CA244327 · NCI · ROCKEFELLER UNIVERSITY · PI BOURNAZOS, STYLIANOS · 2020 to 2024
$3.0MAutoantibodies to tumor-derived neoepitopes as biomarkers and immunoPET agents for the early detection of small cell lung cancerR01CA281801 · NCI · FRED HUTCHINSON CANCER CENTER · PI Delphine L Chen, PAUL D. LAMPE · 2023 to 2026
$2.4MImmunoPET Probes for the Imaging of Lyme DiseaseR01AI175417 · NIAID · HUNTER COLLEGE · PI Maria Gomes-Solecki, WEIGANG QIU · 2023 to 2026
$2.2MThe Development of Radiotherapeutic Paradigms for Desmoplastic Small Round Cell TumorR21CA309945 · NCI · HUNTER COLLEGE · PI Filemon S Dela Cruz, Brian Matthew Zeglis · 2026 to 2026
$431kNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA244327NCI NIH HHS R01 CA281801NCI NIH HHS R21 CA309945NIAID NIH HHS R01 AI175417
6 · The paper itselfAbstract
The current bioconjugation toolbox overwhelmingly comprises strategies that modify lysine and cysteine residues within proteins and peptides. Herein, we have leveraged Frémy's salt (potassium nitrosodisulfonate) to create an approach to bioconjugation predicated on the oxidation of tyrosine residues and the subsequent strain-promoted oxidation-controlled quinone ligation between the resultant 1,2-quinones and
Identifiers
PMID41568207
PMCPMC12818945
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