ArticleNeuro-oncology advances
IGF2 supports glioblastoma growth and immune evasion through a combination of tumor cell-intrinsic and -extrinsic mechanisms.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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17 authors.
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Abstract
Abstract: BackgroundGIntratumoral and intertumoral heterogeneity combined with immunosuppressive tumor microenvironments (TME) contribute to the poor outcomes associated with glioblastoma (GBM). Well-characterized immunocompetent models that recapitulate human GBM features are urgently needed to identify targets in the TME and develop novel therapeutics. Here, we used multiomic approaches to characterize syngeneic mouse brain tumor stem cell lines Methods: Whole-genome sequencing, transcriptomics, ATAC-sequencing, and imaging mass cytometry were used to characterize syngeneic brain tumor stem cell lines derived from Results: One of the syngeneic lines, mBT0309, generated tumors with histopathological characteristics of GBM. mBT0309 displayed amplification and high expression of Conclusions: mBT0309 is a valuable syngeneic model for studying immunosuppression and therapeutic resistance in GBM. IGF2 offers promise as a valuable therapeutic target to combat tumor growth and immunosuppression in GBM patients.
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