Evidence map›Paper›PMID 41568175›Full record

ArticleNeuro-oncology advances

Impact of extent of surgical resection on survival in World Health Organization grade 4 gliomas: A molecular subtype-based analysis.

Ziming Hou, Wenhao Zhang, Zeya Yan, Zihan Wang, Jie Hu, Xing Liu, Shengyu Fang, Tao Jiang, Mian Guo, Hao Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ziming HouDepartment of Neurosurgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China (Z.H., H.W.).ORCID https://orcid.org/0000-0001-5070-3159
Wenhao ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (W.Z., M.G).
Zeya YanDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (Z.Y., Z.W., J.H., S.F., T.J., Y.W.).
Zihan WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (Z.Y., Z.W., J.H., S.F., T.J., Y.W.).
Jie HuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (Z.Y., Z.W., J.H., S.F., T.J., Y.W.).
Xing LiuBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Z.H., X.L., T.J., Y.W.).
Shengyu FangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (Z.Y., Z.W., J.H., S.F., T.J., Y.W.).
Tao JiangBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Z.H., X.L., T.J., Y.W.).
Mian GuoDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China (W.Z., M.G).
Hao WangDepartment of Neurosurgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China (Z.H., H.W.).
Yinyan WangBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Z.H., X.L., T.J., Y.W.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Extensive surgical resection is associated with longer survival in patients with glioma; however, the combined impact of surgical extent and molecular pathology on prognosis remains unclear. In this study, we evaluated how molecular pathology and clinical features influence surgical outcomes in patients with World Health Organization (WHO) grade 4 gliomas, including isocitrate dehydrogenase (IDH)-mutant astrocytomas and IDH wild-type glioblastomas. Methods: Data from 501 patients with WHO grade 4 gliomas who underwent surgery were obtained from the Chinese Glioma Genome Atlas database (2005-2019). The effect of resection extent on overall survival was analyzed and stratified using molecular pathology and clinical characteristics. Survival differences were assessed using the Kaplan-Meier method and the log-rank test, and prognostic factors were identified through univariate and multivariate analyses. Results: The extent of resection significantly influenced survival, but its impact varied by molecular subtype. In WHO grade 4 IDH-mutant astrocytomas, gross total resection (GTR) did not confer a significant survival advantage over subtotal resection (STR). Among glioblastoma patients, those with non-methylated O-(6)-methylguanine-DNA methyltransferase promoters and preoperative Karnofsky Performance Status ≤80 showed no significant benefit from GTR compared to STR, whereas GTR substantially prolonged survival in other subgroups. Conclusions: The survival benefits of extensive resection vary among patients with WHO grade 4 glioma. Molecular pathology and clinical characteristics should be considered in surgical planning. A conservative approach may be appropriate for some patients; nevertheless, a more aggressive strategy may optimize survival and quality of life for others.

Indexed as

Chinese Glioma Genome Atlas | extent of resection | molecular pathology | survival | WHO grade 4 gliomas

Identifiers

PMID41568175
PMCPMC12815601

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