ArticleNeuro-oncology advances
Improved target volume delineation for stereotactic radiosurgery in brain metastases using post-contrast 3D T1 TSE black-blood MRI.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Image-based evaluation of a commercial AI synthetic CT generator for brain and prostate MR-only radiotherapy.Journal of applied clinical medical physics · 2026Article
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9 authors.
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Abstract
Background: Accurate delineation of brain metastases is essential for the success of stereotactic radiosurgery (SRS). This study aimed to compare the morphological and volumetric characteristics of brain metastases using post-contrast 3D T1 gradient-recalled echo (GRE) and 3D T1 black-blood turbo-spin-echo (TSE) sequences. The hypothesis was that gross tumor volumes (GTV) and planning target volumes (PTVs) would be larger on black-blood sequences. Methods: A retrospective review was conducted on 74 adult patients with untreated brain metastases who underwent MRI during a 12-month period. Post-contrast 3D T1 GRE and black-blood TSE sequences were acquired using a 1.5 T MRI. A total of 167 brain metastases were delineated separately by a neuroradiologist and a radiation oncologist, who then determined the consensus GTV and PTV (2 mm). The volumes were then statistically compared using Wilcoxon matched-pairs tests. Results: The inter-observer agreement (DICE index) was higher for black-blood sequences (0.84) than for GRE sequences (0.76). The mean GTV increased significantly from 1.84 cc on GRE sequences to 2.16 cc on black-blood sequences (a 29.8% increase, Conclusion: Post-contrast black-blood sequences produce a significantly larger GTV and PTV than GRE, thereby improving target delineation for SRS. These findings suggest that black-blood MRI should be incorporated into routine planning to optimize treatment accuracy.
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