Evidence map›Paper›PMID 41568169›Full record

ArticleMolecular therapy. Nucleic acids2026

Engineered CRISPR-Cas13a system with enhanced target RNA cleavage activity and reduced collateral activity for therapeutic applications.

Wenxia Zhang, Haili Wang, Dongzi Liu, Xi Mao, Yi Zhang, Yimu Yang, Zehui Liu, Tong Pan, Yingle Liu, Qi Zhang

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenxia ZhangState Key Laboratory of Virology and Biosafety, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Haili WangState Key Laboratory of Virology and Biosafety, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Dongzi LiuState Key Laboratory of Virology and Biosafety, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Xi MaoState Key Laboratory of Virology and Biosafety, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Yi ZhangState Key Laboratory of Virology and Biosafety, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Yimu YangState Key Laboratory of Virology and Biosafety, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Zehui LiuState Key Laboratory of Virology and Biosafety, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Tong PanState Key Laboratory of Virology and Biosafety, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Yingle LiuState Key Laboratory of Virology and Biosafety, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Qi ZhangState Key Laboratory of Virology and Biosafety, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The CRISPR-Cas13 system exhibits potent RNA cleavage activity and has been widely utilized for RNA-targeting applications. However, its collateral cleavage of bystander RNAs limits

Indexed as

antiviral applicationcleavage activitycollateral activityCRISPR-Cas13acrRNAMT: Oligonucleotides: Therapies and Applications

Identifiers

PMID41568169
PMCPMC12818059

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.