ArticleFrontiers in oral health2025
Physicochemical and antibacterial evaluation of novel nano α-TCP-AgNPs biocomposites for direct pulp-capping applications.
Article in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Characterization of nano α-TCP: Setting time, antibacterial activity and cytotoxicity on fibroblast cells.Journal of Taibah University Medical Sciences · 2026Article
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6 authors.
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Abstract
Background: Nano α-tricalcium phosphate (nano α-TCP) and silver nanoparticles (AgNPs) both possess bioactive qualities needed for pulp-capping materials. AgNPs effectively combat microbial infections without sacrificing cell viability, while nano α-TCP releases calcium and phosphate ions necessary for dentin regeneration. To assess the connection between composite structure and function, a thorough characterization utilizing Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), ion-release analysis, and pH measurements is necessary. Purpose: This study aimed to develop and evaluate a novel biocomposite composed of nano α-TCP and AgNPs for application in direct pulp capping. The investigation focused on the material's chemistry and physical properties, as well as its antibacterial activity against Methods: We prepared combinations of nano α-TCP and AgNPs with varying concentrations of AgNPs. Subsequently, we analyzed the composites using XRD, FTIR, and SEM. The investigation also evaluated pH stability and the release of ions (Ca²⁺ and PO₄³⁺) at 1, 3, 72, and 504 h. Antibacterial assays were performed against Results: FTIR and XRD analyses confirmed that the functional groups and crystallinity in the nano α-TCP matrix remained unchanged following incorporation of AgNPs. SEM imaging demonstrated that the particles were uniformly distributed with minimal agglomeration. The 1% AgNPs concentration showed the best results, with a steady release of ions, a stable alkaline pH that helped with mineralization, good mechanical strength (according to ISO 9917-1), and strong antibacterial activity. The 1% AgNPs concentration also had the most potent antibacterial effect. Conclusion: The nano α-TCP/AgNPs composites, particularly the 1% AgNPs formulation, exhibited sustained calcium and phosphate ion release, stable alkaline pH, adequate compressive strength, and strong
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