Evidence map›Paper›PMID 41568134›Full record

ArticleInternational journal of dentistry2026

In Vitro Evaluation and Network Pharmacology Analysis of the Antimicrobial Activity of

Aparna Ganeshkumar, Ram Sabarish, Nadha Shakir, Divya Shree Sankar, Adelyn Jerusha Franklin, Nagalakshmi Gandhi, Kennedy Kumar

Abstract read
In one paragraph

Article in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aparna GaneshkumarDepartment of Periodontics, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, sriramachandra.edu.in.ORCID https://orcid.org/0000-0002-7851-2351
Ram SabarishDepartment of Periodontics, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, sriramachandra.edu.in.ORCID https://orcid.org/0000-0002-2346-4428
Nadha ShakirDepartment of Periodontics, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, sriramachandra.edu.in.ORCID https://orcid.org/0009-0007-4208-9698
Divya Shree SankarDepartment of Periodontics, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, sriramachandra.edu.in.ORCID https://orcid.org/0009-0003-1231-6256
Adelyn Jerusha FranklinDepartment of Periodontics, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, sriramachandra.edu.in.ORCID https://orcid.org/0009-0005-7489-1381
Nagalakshmi GandhiDepartment of Periodontics, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, sriramachandra.edu.in.ORCID https://orcid.org/0009-0001-7286-230X
Kennedy KumarDepartment of Microbiology, Sri Ramachandra Medical College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, sriramachandra.edu.in.ORCID https://orcid.org/0000-0002-5236-6018

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chios mastic gum, a natural resin derived from the mastic tree, has a history of traditional use for its beneficial effects on the gastrointestinal system, its anti-inflammatory properties, and its antimicrobial activity. Objective: This study aimed to integrate network pharmacology and standardized Material and Methods: This study employed a systematic methodology integrating data mining, network construction, and network analysis to explore the intricate relationships between the constituents of mastic gum and their diverse biological targets. The primary active compounds of Results: Four major phytochemicals - alpha-terpineol, linalool, myrcene, and verbenone - were identified as key bioactive compounds. These exhibited favorable pharmacokinetic properties and predicted interactions with targets related to inflammation, oxidative stress, and microbial virulence. Conclusion: The integrative in silico and in vitro analyses indicate that

Indexed as

anti-infective agentsantimicrobial resistancedrug discoverynetwork pharmacologyphytotherapy

Identifiers

PMID41568134
PMCPMC12817137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.