ArticleCHEST critical care2025
Association Between Receipt of Ketamine vs Etomidate for Emergency Tracheal Intubation and Symptoms of Posttraumatic Stress Disorder at 12 Months.
Abstract read
In one paragraph
Article in CHEST critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Lucas C WollenmanDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Austin M TipoldDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Matthew W SemlerDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Jonathan D CaseyDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Aaron J LacyDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Wesley H SelfDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Amy L KiehlDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Patsy T BryantDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Stephanie C DeMasiDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Ian H StanleyDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Cathy A JenkinsDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Guanchao WangDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Jim C JacksonDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
E Wes ElyDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Jin H HanDepartment of Emergency Medicine (L. C. W., A. M. T., W. H. S., S. D., and J. H. H.), the Division of Allergy, Pulmonary, and Critical Care Medicine (M. W. S., J. D. C., A. L. K., P. T. B., J. C. J., and E. W. E.), Department of Medicine, the Vanderbilt Institute for Clinical and Translational Research (M. W. S., J. D. C., and W. H. S.), the Critical Illness, Brain Dysfunction, and Survivorship Center (A. L. K., P. T. B., J. C. J., E. W. E., and J. H. H.), the Department of Biostatistics (C. A. J., and G. W.), Vanderbilt University Medical Center; the Geriatric Research, Education, and Clinical Center (J. C. J., E. W. E., and J. H. H.), Tennessee Valley Healthcare Center, Nashville, TN; the Department of Emergency Medicine (A. J. L.), Washington University, St. Louis, MO; and the Department of Emergency Medicine (I. H. S.), University of Colorado School of Medicine, Aurora, CO.
Funding
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MCognitive Outcomes in the Pragmatic Investigation of Optimal Oxygen Targets (CO-PILOT) TrialR21AG063126 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAN, JIN HO · 2020 to 2021
$468kNCATS NIH HHS UL1 TR000445NIA NIH HHS R21 AG063126
Abstract
backgroundOne of 3 patients in the ICU receiving mechanical ventilation demonstrates posttraumatic stress disorder (PTSD). A single dose of ketamine has been shown to reduce PTSD symptoms in outpatients with chronic PTSD, but its long-term effect is unknown in patients who are critically ill and mechanically ventilated. RESEARCH QUESTION: Is ketamine, when used for induction of anesthesia before emergency tracheal intubation, associated with fewer symptoms of PTSD at 12 months compared with etomidate? STUDY DESIGN AND
methodsThis was a secondary analysis of a cluster-randomized trial that examined the effect of oxygen saturation targets in patients receiving invasive mechanical ventilation in an emergency department or ICU. Symptoms of PTSD were assessed by trained neuropsychologist raters using the PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (PCL-5) by phone. Scores ranged from 0 to 80, with higher scores indicating more severe PTSD symptoms. A score of ≥ 31 indicated probable PTSD. Symptoms of PTSD were compared between patients who received ketamine and patients who received etomidate using a proportional odds logistic regression model adjusting for age, race, sex, education, depression or PTSD before illness, comorbidities, severity of illness, sepsis, and location of intubation.
resultsAmong the 141 patients included in this analysis, 52 patients (37%) received ketamine and 89 patients (63%) received etomidate. The median PCL-5 score at 12 months was 7 (interquartile range [IQR], 1-18) for patients who received ketamine and 14 (IQR, 5-27) for patients who received etomidate (reference; adjusted OR, 0.39; 95% CI, 0.20-0.76). A total of 8 patients (15.4%) who received ketamine and 18 patients (20.2%) who received etomidate met criteria for probable PTSD.
conclusionsCompared with etomidate, induction with ketamine during emergency tracheal intubation was associated with significantly fewer symptoms of PTSD at 12 months. A randomized trial is needed to confirm this finding.
Indexed as
anxietydepressionemergent tracheal intubationetomidateketaminelong-term cognitive impairmentposttraumatic stress disorder
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.