ArticleBiochemistry and biophysics reports2026
Integrated bioinformatics and tissue-based validation reveal the oncogenic role of hsa_circ_0043256 and hsa_circ_0004789 in gastric cancer.
Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) play a key role in gastric cancer (GC) pathogenesis. This study hsa_circ_0043256 and hsa_circ_0004789, and their interactions with miR-28-5p/Cyclin B1 (CCNB1) and miR-5683/CCNB1, via bioinformatic and experimental methods. We retrieved expression data for circRNAs, miRNAs, and mRNAs in GC from Gene Expression Omnibus and The Cancer Genome Atlas. Using online databases and R tools, we identified downstream miRNAs and target mRNAs to build a competing endogenous RNA (ceRNA) network. After identification of hub genes and performing functional enrichment, we defined two regulatory axes: hsa_circ_0043256/miR-28-5p/CCNB1 and hsa_circ_0004789/miR-5683/CCNB1. We studied 32 paired tumor and adjacent tissues to assess all genes and CCNB1 protein expression, along with correlations, histopathological associations, ROC curves, and survival outcomes. We identified 58 circRNAs, 123 miRNAs, and 2126 mRNAs, and, further, by novelty checking and downstream RNA analysis, identified two axes. The expression of hsa_circ_0043256, hsa_circ_0004789, and CCNB1 mRNA and protein levels was elevated, while miR-28-5p and miR-5683 levels were reduced. Correlations observed among axis components supported the ceRNA hypothesis. The hsa_circ_0004789/miR-5683/
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.