Observational studyFrontiers in endocrinology2025
Changes of the cardiac electrical cycle in type 1 diabetes during hypoglycaemia - a prospective observational study.
Observational study in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The "dead-in-bed" syndrome is thought to be a consequence of hypoglycaemia-induced QTc prolongation in type 1 diabetes. Thus, we characterized electrocardiogram (ECG) changes during hypoglycaemia in healthy, free-living patients with type 1 diabetes without major comorbidities. Methods: A cohort of n=23 patients with type 1 diabetes wore continuous subcutaneous glucose and ECG monitors for approximately 7 days. We compared the frequency of ventricular premature beats (VPBs), the mean and SD of heart rate, and ECG intervals during hypoglycaemic episodes and their respective control episodes (n=226 episodes; n=1,697,205 beats) using linear mixed models. Results: The mean duration of hypoglycaemic episodes was 159 min (95% CI: 128 Discussion: Daytime hypoglycaemia is an unlikely cause of malignant arrhythmias in healthy patients with type 1 diabetes. The minimal increase in the QTc interval alone does not suggest an increased risk of malignant arrhythmias. However, the increase in the mean QTc together with an increase in its SD during nighttime hypoglycaemia is compatible with the extremely rare occurrence of the "dead-in-bed" syndrome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.