ArticleMaterials today. Bio2026
Ferritin-nanocaged aggregation-induced emission nanoaggregates for integrated sensitive detection and treatment of gastric cancer.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gastric cancer remains a global health challenge due to late diagnosis and limited targeted therapies. Herein, we report a novel dual-targeted nanoplatform, AIE@HFn-scfv, integrating aggregation-induced emission luminogens (AIEgens) with human heavy-chain ferritin (HFn) conjugated to Claudin18.2-specific single-chain variable fragments (scFv). This nanoconstruct leverages HFn's natural affinity for transferrin receptor 1 (CD71) and scFv-mediated targeting of Claudin18.2 to achieve precise tumor localization. Bioinformatics analysis confirmed co-overexpression of CD71 and Claudin18.2 in gastric cancer tissues, validating their utility as dual targets. Physicochemical characterization revealed stable nanoparticles (∼17 nm) with pH-responsive fluorescence and efficient AIEgens encapsulation.
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