ArticleAmerican journal of clinical and experimental immunology2025
Causal effects and metabolite mediation of immune cells in preterm birth: a Mendelian randomization study.
Article in American journal of clinical and experimental immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPreterm birth poses significant risks to neonatal health. Although immune dysregulation has been implicated in its etiology, the causal roles of specific immune cell phenotypes and the potential mediating effects of metabolites remain unclear. This study applied Mendelian randomization (MR) to investigate causal relationships between immune cell phenotypes and preterm birth, and to assess whether plasma metabolites mediate these associations.
methodsTwo-sample and mediation MR analyses were performed using genetic variants from genome-wide association studies (GWAS) of immune cells and plasma metabolites. Causal estimates were primarily derived using inverse variance weighting (IVW), with sensitivity analyses conducted via MR-Egger, MR-PRESSO, and leave-one-out validation.
resultsA total of 28 immune cell phenotypes and 47 metabolites were robustly associated with preterm birth (P < 0.05). Reverse MR analysis revealed no evidence of reverse causality for the identified immune phenotypes. Among these, CD28
conclusionThis study establishes causal links between immune cell phenotypes, metabolites, and genetic susceptibility to preterm birth. Specifically, CD28
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