SynthesisFrontiers in medicine2025
The effect of intraoperative hypotension on postoperative delirium: a meta-analysis and systematic review.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Perioperative neurocognitive disorders in older patients: a narrative review of current knowledge in 2026.Perioperative medicine (London, England) · 2026Review
- Correlation between frailty status and prolonged length of stay in the post-anesthesia care unit and development of a predictive model in elderly patients undergoing painless gastrointestinal endoscopy.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative delirium (POD) is a common complication linked to poor outcomes, yet its relationship with intraoperative hypotension (IOH) remains unclear. The objective of this study was to clarify the association between intraoperative IOH and POD. Method: We searched four databases (PubMed, EMBASE, Cochrane Library, and Web of Science) from their inception to June 14, 2025. Randomized controlled trials (RCTs) and observational studies were included when IOH was incorporated as a predictive variable for POD in adult patients undergoing elective surgery under general anesthesia. Risk ratio (RR) and odds ratio (OR) were calculated using a random-effect model separately in RCTs and observational studies. Results: In total, thirty out of 1,261 studies were included for the systematic review, of which 18 studies were eligible for quantitative meta-analysis. The remaining 12 studies were excluded due to incompatible data formats: eight used continuous metrics, and four lacked extractable effect estimates. IOH was significantly associated with an elevated risk of POD in both RCTs (RR: 1.89, 95%CI: 1.31-2.74) and observational studies (OR: 2.48, 95%CI: 1.64-3.75). Subgroup analysis of observational studies revealed that IOH defined by absolute threshold (OR: 4.11, 95%CI: 2.05-8.24) and mean arterial pressure (MAP) (OR: 2.90, 95%CI: 1.56-5.39) was related to a higher risk of POD. This heterogeneity was further explored by meta-regression, which identified the threshold nature of the IOH definition as a significant source of heterogeneity and a key effect modifier ( Conclusion: Our meta-analysis demonstrates a statistically significant association between IOH and increased risk of POD. However, substantial methodological heterogeneity across the included studies limits the robustness of these findings. The current evidence should therefore be interpreted as exploratory, highlighting the need for more standardized investigations in this field. Systematic review registration: Identifier CRD42023424166.
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