ArticleFrontiers in pharmacology2025
Activity-based chemoproteomic profiling reveals the active kinome of
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Methods: We applied activity-based protein profiling (ABPP) with custom in-house cell-permeable ATP-site directed probes to map the ligandable, "active kinome" of Results: We uncovered 16 metabolic kinases and 32 protein kinases spanning all major kinase families (CMGC, AGC, STE, CAMK, CK1, and NEK), including nine protein kinase enzymes encoded by essential genes and several kinases lacking human orthologs. Notable hits included CRK1, MPK4, CK1.2, and an atypical kinase, underscoring their potential as drug targets. Conclusion: This study provides the first ABPP survey of the
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