Evidence map›Paper›PMID 41567554›Full record

ArticleFood chemistry: X2026

Molecular mechanism of synergistic tyrosinase inhibition by blueberry and black chokeberry anthocyanidins: Optimal synergistic formulation for multi-berry beverage development.

Yuxin Du, Lanqiong Zhao, Zixuan Yuan, Yu Zhang, Yuxin Chen, Yang Ding, Xinyao Jiao, Chong Zhao, Kuniyoshi Shimizu, Baoru Yang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuxin DuCollege of Food Science, Shenyang Agriculture University, Shenyang, Liaoning 110866, China.
Lanqiong ZhaoCollege of Food Science, Shenyang Agriculture University, Shenyang, Liaoning 110866, China.
Zixuan YuanCollege of Food Science, Shenyang Agriculture University, Shenyang, Liaoning 110866, China.
Yu ZhangCollege of Food Science, Shenyang Agriculture University, Shenyang, Liaoning 110866, China.
Yuxin ChenCollege of Food Science, Shenyang Agriculture University, Shenyang, Liaoning 110866, China.
Yang DingCollege of Food Science, Shenyang Agriculture University, Shenyang, Liaoning 110866, China.
Xinyao JiaoCollege of Food Science, Shenyang Agriculture University, Shenyang, Liaoning 110866, China.
Chong ZhaoCollege of Food Science and Nutritional Engineering, China Agriculture University, Beijing 100083, China.
Kuniyoshi ShimizuDepartment of Agro-Environmental Sciences, Faculty of Agriculture, Kyushu University, 812-8581 Fukuoka, Japan.
Baoru YangFood Chemistry and Food Development, Department of Life Technologies, University of Turku, FI-20014 Turun yliopisto, Finland.
Zhongxia LiNutrition and Health Research Centre, By-Health Co. Ltd, Guangzhou, China.
Bin LiCollege of Food Science, Shenyang Agriculture University, Shenyang, Liaoning 110866, China.
Hui TanCollege of Food Science, Shenyang Agriculture University, Shenyang, Liaoning 110866, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tyrosinase is the rate-limiting enzyme in melanogenesis and food browning, making its inhibitors crucial for health and food preservation. However, the specific mechanisms by which multi-berry formulations synergistically inhibit tyrosinase remain uncharacterized, particularly within the context of overcoming bioactivity limitations caused by standardized food ingredients. Our study revealed that blueberry-black chokeberry extracts at 1:1 ratio with superior synergistic inhibition in tyrosinase. Using affinity-ultrafiltration coupled with ultra-performance liquid chromatography-mass spectrometry (AUF-UPLC-MS), sixteen inhibitors were identified, notably delphinidin-3-

Indexed as

AnthocyaninFood controlInteraction mechanismSynergistic effectTyrosinase

Identifiers

PMID41567554
PMCPMC12818235

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.