ArticleFrontiers in neurology2025
A burden of nerve injury from a global perspective, 1990-2021: an analysis of incidence, prevalence, and years lived with disability.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Metabolic targeting by a small extracellular vesicle-based cellulose-GelMA hydrogel restores neurovascular regeneration in diabetic nerve injury.Bioactive materials · 2027Article
- Melatonin in Peripheral Nerve Regeneration: Molecular Mechanisms, Schwann Cell Dynamics, and Translational Therapeutic Potential.Molecular neurobiology · 2026Review
- Article
- Grip strength as a translational biomarker for peripheral nerve injury and recovery.Frontiers in neuroscience · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
Objective: To provide a solid foundation for the prevention, treatment, and reduction of the incidence of nerve injury, we explain and update the changes in the epidemiology of nerve injury from 1990 to 2021. Methods: We did our analysis employing the 2021 Global Burden of Disease, Injury and Risk Factor Study to calculate the incidence, prevalence and YLDs of nerve injury between 1990 and 2021 at the global, regional and national levels. The analysis was done according to gender, age group and region in layers. Results: In 2021, globally, there were 4.13 million [95% uncertainty interval (UI): 3.11-5.56] instances of nerve injury, featuring an age-standardized incidence and prevalence of 53 cases per 100,000 people, respectively (95% UI: 40-72) and 51 cases per 100,000 people (95% UI: 47-57). The global age-standardized incidence had an Average Annual Percent Change (AAPC) of -1.03% (95% UI: -1.38 - 0.68, Conclusion: This study focused on the occurrence of nerve injury from 1990 to 2021, and discovered that the global incidence rate went down a little, different SDI areas and regions had big differences, and the prevalence rate increased in some regions. It provides strong support for further exploring the causes of nerve injury and formulating future policies and protection measures.
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