Evidence map›Paper›PMID 41567543›Full record

ArticleFrontiers in neurology2025

Very early tilt-table verticalization unmasks impaired cerebral autoregulation within 24 h after endovascular thrombectomy: a transcranial Doppler study.

Julian Deseoe, Yannik Rottenberger, Theodor Pipping, Anne Schwarz, Aurelia Lehmann, Janne M Veerbeek, Susanne Wegener, Andreas R Luft, Jeremia P O Held, Christoph Globas

Registry-linked trialAbstract read
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In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04573114 (Cerebral Hemodynamics During Early Verticalization After), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04573114 unknown statusnot on this map

Cerebral Hemodynamics During Early Verticalization After (Successful) Thrombectomy Poststroke

TypeobservationalSponsorUniversity of ZurichRan2020 to 2022Enrolled80ConditionsStroke, HealthyArmsVerticalization
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julian DeseoeDepartment of Neurology, University Hospital Zurich and University of Zurich, Zürich, Switzerland.
Yannik RottenbergerDepartment of Neurology, University Hospital Zurich and University of Zurich, Zürich, Switzerland.
Theodor PippingDepartment of Neurology, University Hospital Zurich and University of Zurich, Zürich, Switzerland.
Anne SchwarzDepartment of Neurology, University Hospital Zurich and University of Zurich, Zürich, Switzerland.
Aurelia LehmannDepartment of Neurology, University Hospital Zurich and University of Zurich, Zürich, Switzerland.
Janne M VeerbeekDepartment of Neurology, University Hospital Zurich and University of Zurich, Zürich, Switzerland.
Susanne WegenerDepartment of Neurology, University Hospital Zurich and University of Zurich, Zürich, Switzerland.
Andreas R LuftDepartment of Neurology, University Hospital Zurich and University of Zurich, Zürich, Switzerland.
Jeremia P O HeldDepartment of Neurology, University Hospital Zurich and University of Zurich, Zürich, Switzerland.
Christoph GlobasDepartment of Neurology, University Hospital Zurich and University of Zurich, Zürich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Impaired cerebral autoregulation in the acute phase after ischemic stroke may compromise cerebral perfusion during very early mobilization, posing a risk for secondary injury. Methods: This observational cross-sectional study investigated the mechanistic response of cerebral and systemic hemodynamics during progressive tilt-table verticalization in 25 patients within 24 h post-thrombectomy and 31 healthy age-matched controls. Middle cerebral artery blood flow velocity (CBFV) was continuously recorded via transcranial Doppler across six full-body tilt positions (-5° to 70°), alongside blood pressure, heart rate, and oxygen saturation. Results: CBFV declined progressively with increasing tilt in both groups ( Discussion: Our results suggest impairments in cerebral and systemic vascular control mechanisms in acute stroke patients post thrombectomy. These results provide further insight into the physiological constraints limiting early verticalization and underscore the value of real-time CBFV monitoring as a potential biomarker for autoregulatory integrity. Incorporating individualized hemodynamic profiling may enhance safety and precision in early stroke rehabilitation protocols. Clinical trial registration: ClinicalTrials.gov, identifier NCT04573114.

Indexed as

blood pressurecerebral autoregulationDoppler ultrasoundischemic strokevery early mobilization

Identifiers

PMID41567543
PMCPMC12815858

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.