Evidence map›Paper›PMID 41567428›Full record

ArticleFrontiers in pediatrics2025

Amniotic fluid neutrophil gelatinase-associated lipocalin and L-type fatty acid-binding protein levels in predicting long-term prognosis in fetal growth restriction and preterm birth: a preliminary study.

Daisuke Katsura, Shunichiro Tsuji, Shinsuke Tokoro, Ayako Inatomi, Nobuyuki Kita, Takashi Murakami

Abstract read
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daisuke KatsuraDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, Japan.
Shunichiro TsujiDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, Japan.
Shinsuke TokoroDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, Japan.
Ayako InatomiDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, Japan.
Nobuyuki KitaDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, Japan.
Takashi MurakamiDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The fetal intrauterine environment, including inflammation and fetal hypoxia, influences both short- and long-term prognoses. Urinary neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP) levels are associated with inflammation and organ hypoperfusion, respectively. In this study, we evaluated the association between amniotic fluid NGAL and L-FABP levels measured at delivery and long-term outcomes. Methods: Adverse outcomes were defined as hearing loss, neurodevelopmental impairment, and cerebral palsy. Thirty-one singleton pregnancies were categorized into groups with (AD group, Results: Significant differences in the prevalence of fetal blood flow abnormalities ( Discussion: Amniotic fluid NGAL and L-FABP levels were associated with adverse long-term outcomes, providing preliminary, proof-of-concept evidence of their potential prognostic relevance. Further prospective studies with larger cohorts are needed to validate these findings and clarify their clinical applicability.

Indexed as

amniotic fluidinfant mortalitylong-term prognosisl-type fatty acid-binding proteinneonatal mortalityneutrophil gelatinase-associated lipocalin

Identifiers

PMID41567428
PMCPMC12816317

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.