Evidence map›Paper›PMID 41567425›Full record

ArticleFrontiers in pediatrics2025

Study protocol for the volume targeted mask ventilation versus pressure ventilation in preterm infants-the VOLT-trial.

Brenda H Y Law, Maryna Yaskina, Peter G Davis, Graeme Polglase, Michael Dunn, Amit Mukerji, Georg M Schmölzer

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05144724 (Volume Targeted Mask Ventilation Versus Pressure Ventilation in Preterm Infants), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05144724 nacompletednot on this map

Volume Targeted Mask Ventilation Versus Pressure Ventilation in Preterm Infants

TypeinterventionalSponsorUniversity of AlbertaRan2024 to 2025Enrolled52ConditionsNeonatal Respiratory DistressArmsVolume targeted ventilation, Pressure targeted ventilation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brenda H Y LawCentre for the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Edmonton, AB, Canada.
Maryna YaskinaWomen and Children's Health Research Institute (WCHRI), University of Alberta, Edmonton, AB, Canada.
Peter G DavisDepartment of Neonatology, The Royal Women's Hospital, University of Melbourne, Melbourne, VIC, Australia.
Graeme PolglaseThe Ritchie Centre, Department of Paediatrics, Monash University, Hudson Institute of Medical Research, Melbourne, VIC, Australia.
Michael DunnDepartment of Paediatrics, University of Toronto, Toronto, ON, Canada.
Amit MukerjiDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Georg M SchmölzerCentre for the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The rapid establishment of gas exchange after birth is vital for survival and long-term health. When newborn infants fail to initiate spontaneous breathing, positive pressure ventilation (PPV) is the cornerstone of respiratory support immediately after birth. The aim of PPV is to inflate the lungs, create a functional residual capacity, deliver an adequate tidal volume (V Methods: A randomized trial of VTV-PPV vs. PPV during neonatal resuscitation in preterm infants at birth to assess feasibility of a definitive trial for the intervention. Preterm infants born between 23 Discussion: The VOLT-trial aims to assess feasibility of VTV-PPV and will address gaps in the evidence regarding the optimal approach to the establishment of ventilation in the delivery room. We aim to use to results of this trial to inform the design of a large multi-centre trial. Study Protocol Registration: https://clinicaltrials.gov/study/NCT05144724, identifier NCT05144724.

Indexed as

delivery roomextremely preterminfantneonatal intensive careneonatal mortalityrespiratory function tests

Identifiers

PMID41567425
PMCPMC12816339

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.