Evidence map›Paper›PMID 41567422›Full record

ArticleFrontiers in pediatrics2025

Diagnostic efficacy of fecal markers combined with alarm symptoms in distinguishing functional and organic abdominal pain in children.

Junhong Liu, Bin Wu, Bihong Ma, Xiaoyan Zhang

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Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Junhong LiuDepartment of Pediatrics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Bin WuDepartment of Pediatrics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Bihong MaDepartment of Pediatrics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Xiaoyan ZhangDepartment of Pediatrics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study assessed the diagnostic potential of fecal markers, calprotectin (FC), and occult blood (OB), in conjunction with alarm symptoms and blood markers, to differentiate functional abdominal pain (FAP) from organic disease in children. Methods: We conducted a retrospective review of children with chronic abdominal pain who presented between April 2017 and April 2020, which included 347 classified as FAP and 224 classified as organic disease. Children with constipation in the functional group were included, and a slight elevation in FC in that group was considered non-inflammatory. FC interpretation included age/sex norms as opposed to percentiles, utilizing the cutoff of 60 µg/g, with justification given by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition diagnostic criteria ( Results: The organic disease had significantly greater alarm symptoms and abnormal fecal and blood indices compared with FAP ( Conclusion: The combination of alarm symptoms with fecal FC and OB tests provides a sensitive and specific non-invasive strategy for the differentiation of organic from FAP in children. The mild elevation of FC is likely indicative of functional constipation rather than inflammation, and attention should be given to diet and substances that affect OB outcome, specifically in children.

Indexed as

chronic abdominal painfecal calprotectinfecal occult blood testfunctional abdominal painROC curve

Identifiers

PMID41567422
PMCPMC12816174

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.