ArticleFrontiers in nutrition2025
Crotonylation-related gene
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Lactate-driven lactylation reprograms chondrocyte fate and joint inflammation in osteoarthritis: linking metabolism with epigenetic regulation.Frontiers in cell and developmental biology · 2026Review
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Authors and funding
7 authors.
Funding
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Abstract
Introduction: Osteoarthritis (OA) is a prevalent degenerative joint disorder characterized by progressive cartilage degradation and synovial inflammation. This study is designed to elucidate the role of crotonylation genes in OA progression. Materials and methods: The crotonylation genes exposure and OA outcome data were obtained from the eQTLGen consortium and UK Biobank databases, respectively. Mendelian randomization analysis was employed to establish mechanistic links between crotonylation genes and OA, with subsequent validation conducted through cartilage RNA sequencing (RNA-seq) data. GCDH expression and its regulatory effects on key extracellular matrix (ECM) markers were assessed by Western blot (WB) and quantitative real-time polymerase chain reaction (qRT-PCR) in OA chondrocytes. Moreover, CCK-8, EdU and Transwell assays were utilized to assess differences in chondrocyte proliferation and migration potential at the time of OA versus after Results: The study identified Conclusion: The crotonylation gene
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