Evidence map›Paper›PMID 41567292›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2025

Increased Plasma Concentrations of 6-oxo-Methylphenidate in

Qingchen Zhang, Philip W Melchert, Ahmed Awad, Christopher R McCurdy, Beth Krone, Jeffrey Newcorn, Tanya E Froehlich, Mark A Stein, Josephine Raeuscher, Hao-Jie Zhu and 1 more

Abstract read
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In one paragraph

Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qingchen ZhangDepartment of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA.
Philip W MelchertDepartment of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA.
Ahmed AwadDepartment of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610, USA.
Christopher R McCurdyDepartment of Medicinal Chemistry, University of Florida, Gainesville, FL, 32610, USA.
Beth KroneDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.
Jeffrey NewcornDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.
Tanya E FroehlichDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA.
Mark A SteinDepartment of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.
Josephine RaeuscherDepartment of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA.
Hao-Jie ZhuDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, 48109, USA.
John S MarkowitzDepartment of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, 32610, USA.

Funding

Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHDR01HD093612 · NICHD · UNIVERSITY OF FLORIDA · PI MARKOWITZ, JOHN S, ZHU, HAOJIE · 2018 to 2022
$3.0M
NICHD NIH HHS R01 HD093612
6 · The paper itself

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder, with methylphenidate used as a first-line treatment. Methylphenidate is primarily hydrolyzed by carboxylesterase 1 (CES1) to inactive ritalinic acid, with minor oxidative metabolism producing active p-OH-methylphenidate and 6-oxo-methylphenidate lactam. The functional single-nucleotide polymorphism (SNP) in

Indexed as

6-oxo-MethylphenidateADHDCES1 G143EMethylphenidatePharmacokinetics

Identifiers

PMID41567292
PMCPMC12818952

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.