Evidence map›Paper›PMID 41567265›Full record

ArticleOpen forum infectious diseases2026

Clinical Characteristics and Management of Non-Tuberculous Mycobacterial Skin and Soft Tissue Infections: A Retrospective Cohort Study.

Wouter Peeters, Chang van Lier, Jakko van Ingen, Claire van Houdt, Reinout van Crevel, Colette van Hees, Hannelore Bax, Juul van den Reek, Arjan van Laarhoven

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wouter PeetersDepartment of Internal Medicine and Radboud Community for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0009-0003-4034-1686
Chang van LierDepartment of Internal Medicine and Radboud Community for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Jakko van IngenDepartment of Medical Microbiology and Radboud Community for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-0581-2003
Claire van HoudtDepartment of Plastic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Reinout van CrevelDepartment of Internal Medicine and Radboud Community for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-6233-6410
Colette van HeesDepartment of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-2240-4327
Hannelore BaxDepartment of Internal Medicine, Section of Infectious Diseases and Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0003-0076-5479
Juul van den ReekDepartment of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-3642-2673
Arjan van LaarhovenDepartment of Internal Medicine and Radboud Community for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-6607-4075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Non-tuberculous mycobacterial (NTM) skin and soft tissue infections (SSTI) present a significant treatment challenge, requiring prolonged, multidrug antibiotic regimens often associated with substantial toxicity and suboptimal clinical outcomes. We aim to describe the clinical characteristics and treatment of patients with NTM-SSTI in the Netherlands, focusing on host immune status and drug toxicity. Methods: We retrospectively collected data from adults with NTM-SSTI treated at 2 Dutch tertiary referral centers for mycobacterial disease between 2017 and 2024. Data included sociodemographics, medical history, antibiotic regimens, drug toxicity, and treatment outcomes. Results: We included 73 patients, of whom 39 (49%) were immunocompromised. Disseminated disease was almost exclusively observed in immunocompromised patients (14/15). The most isolated species were Conclusions: Immunocompromised status is associated with disseminated NTM-SSTI and worse treatment outcomes. Regardless of immune status, antimycobacterial drugs often cause toxicity, leading to treatment changes.

Indexed as

drug toxicitymycobacterium chelonaemycobacterium marinumnon-tuberculous mycobacteriaskin and soft tissue infections

Identifiers

PMID41567265
PMCPMC12817974

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.