Evidence map›Paper›PMID 41567246›Full record

ArticleiScience2026

The GF-NEO discovery platform unveils a [KQE][DG] sequence motif within fusion neoantigens in pediatric cancer.

Christopher Savoie, Zhaoguan Wu, Frederic Saab, Tristan St-Laurent, Lou Nielly Thibault, Charles B Beauparlant, Marc-André Déry, Nehme El-Hachem, Bayrem Gharsallaoui, Samuel-Joseph Tremblay and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Christopher SavoieCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Zhaoguan WuCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Frederic SaabCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Tristan St-LaurentCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Lou Nielly ThibaultCentre de recherche du CHU de Québec, Université Laval, Québec, QC G1E 6W2, Canada.
Charles B BeauparlantCentre de recherche du CHU de Québec, Université Laval, Québec, QC G1E 6W2, Canada.
Marc-André DéryCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Nehme El-HachemCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Bayrem GharsallaouiCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Samuel-Joseph TremblayCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Anna SabouretCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Nadia Emely Chauca TorresCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Mélanie BilodeauCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Éric BonneilInstitut de Recherche en Immunologie et Cancérologie, Montréal, QC H3T 1J4, Canada.
John SidneyLa Jolla Institute for Allergy, San Diego, CA 92037, USA.
Alessandro SetteLa Jolla Institute for Allergy, San Diego, CA 92037, USA.
Arnaud DroitCentre de recherche du CHU de Québec, Université Laval, Québec, QC G1E 6W2, Canada.
Pierre ThibaultInstitut de Recherche en Immunologie et Cancérologie, Montréal, QC H3T 1J4, Canada.
Sonia CellotCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Étienne CaronDepartment of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
Isabelle SiroisCentre de recherche de l'Hôpital Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene fusions (GFs) are critical events in pediatric oncology, often serving as oncogenic drivers. However, fusion proteins and their derived neoantigens (GF-NEOs) remain underexplored for targeted immunotherapy. We developed ProteoFusioNEO, a computational tool for the

Indexed as

Biological sciences toolsCancerIn silico biologyOmics

Identifiers

PMID41567246
PMCPMC12818165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.