ArticleJournal of vascular surgery cases and innovative techniques2026
A case of protein S-specific activity triggers detection with potential thrombosis development.
Article in Journal of vascular surgery cases and innovative techniques, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Protein S gene abnormalities are the most common congenital predisposition to thrombophilia in the Japanese population, but not in the Caucasian population. It is important to measure protein S activity, specific activity, and antigen levels in patients with thrombophilia. A 52-year-old man presented with suspected deep vein thrombosis after previously visiting an orthopedic clinic with right lower extremity swelling after his long-distance walk 5 days prior. His D-dimer level was elevated, and a thrombus was found from the femoral to the below-the-knee veins on ultrasonographic echography. Anticoagulation therapy was initiated. His parents had previously been diagnosed with deep vein thrombosis; therefore, he was examined for thrombophilic predisposition. The results showed normal protein S activity and antigen levels, but decreased protein S-specific activity. Genetic testing revealed the presence of a protein S variant (protein S Tokushima). In addition to measuring protein activity and antigen levels, protein S-specific activity measurements can reveal increased risks of thrombosis.
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