Evidence map›Paper›PMID 41567076›Full record

ArticleJournal of medicinal chemistry2026

The Discovery of RGH-706, a Highly Efficacious MCH1 Receptor Antagonist, for the Treatment of Obesity and Insatiable Hunger.

Gyula Beke, András Boros, György M Keserű, Balázs Krámos, Krisztina Katalin Szalai, Anikó Gere, Mónika Vastag, Márta Thán, Balázs Varga, Ottilia Balázs and 4 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gyula BekeGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.ORCID 0000-0001-6122-3417
András BorosGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.
György M KeserűGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.ORCID 0000-0003-1039-7809
Balázs KrámosGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.ORCID 0000-0002-6387-7382
Krisztina Katalin SzalaiGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.ORCID 0000-0001-9416-736X
Anikó GereGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.
Mónika VastagGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.
Márta ThánGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.
Balázs VargaGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.
Ottilia BalázsGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.
Sándor FarkasGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.
Balázs LendvaiGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.
István GreinerGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.
János ÉlesGedeon Richter Plc., 19-21 Gyömrői út, Budapest 1103, Hungary.ORCID 0000-0001-9185-1123

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery and characterization of a novel 2,3,4,5-tetrahydro-1

Indexed as

Anti-Obesity AgentsAzepinesIndolesObesityReceptors, SomatostatinAnimalsDrug DiscoveryHumansMaleMiceStructure-Activity RelationshipAnti-Obesity AgentsAzepinesIndolesMCHR1 protein, humanReceptors, Somatostatin

Identifiers

PMID41567076
PMCPMC13126673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.