Evidence map›Paper›PMID 41567036›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2026

Loneliness patterns across time and subsequent risk of psychotic experiences, depression, anxiety, and diminished well-being in adolescents.

Zui C Narita, Jordan DeVylder, Gemma Knowles, Syudo Yamasaki, Mitsuhiro Miyashita, Daniel Stanyon, Satoshi Yamaguchi, Tomohiro Shinozaki, Ryo Sasaki, Rui Zhou and 7 more

Abstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zui C NaritaDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID 0000-0001-7022-2141
Jordan DeVylderSilver School of Social Work, New York University, New York, New York, USA.
Gemma KnowlesEconomic and Social Research Council (ESRC) Center for Society and Mental Health and Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID 0000-0001-6107-3957
Syudo YamasakiUnit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Mitsuhiro MiyashitaUnit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Daniel StanyonEconomic and Social Research Council (ESRC) Center for Society and Mental Health and Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Satoshi YamaguchiUnit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID 0000-0002-3988-1330
Tomohiro ShinozakiInterfaculty Initiative in Information Studies, Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ryo SasakiUnit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Rui ZhouUnit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Shuntaro AndoUnit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Craig MorganEconomic and Social Research Council (ESRC) Center for Society and Mental Health and Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Paola DazzanDepartment of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Toshiaki A FurukawaDepartment of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan.
Kiyoto KasaiDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ian KelleherDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-1484-651X
Atsushi NishidaUnit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Funding

Japan Agency for Medical Research and Development JP23wm0625001Japan Agency for Medical Research and Development JP25oa0439005Japan Science and Technology Agency JPMJPF2105Japan Science and Technology Agency RISTEX JPMJRS24K1Japan Society for the Promotion of Science JP21H05171Japan Society for the Promotion of Science JP21H05173Japan Society for the Promotion of Science JP21H05174Japan Society for the Promotion of Science JP23H05472Japan Society for the Promotion of Science JP24H00666Japan Society for the Promotion of Science JP25K00889Japan Society for the Promotion of Science JP25K20564Wellcome TrustWellcome Trust 309118/Z/24/Z
6 · The paper itself

Abstract

backgroundEvidence on the association between loneliness and psychotic experiences in adolescents remains limited. Moreover, loneliness has typically been assessed at a single time point, which fails to capture its dynamic nature. We hypothesized that persistent loneliness, assessed across repeated measures, would be associated with psychotic experiences and other mental health problems.

methodsUsing longitudinal data from 3,171 participants in the Tokyo Teen Cohort, we applied the g-formula. We analyzed how loneliness patterns at ages 12 and 14 were associated with psychotic experiences, depression, anxiety, and diminished well-being at age 16, accounting for time-fixed and time-varying confounders. Missing data were handled using multiple imputation by chained equations.

resultsPersistent loneliness was associated with increased risk and greater severity of psychotic experiences (RD 7.1%, 95% CI: 0.8-14.3; RR 2.44, 95% CI: 1.16-4.11; β 0.28, 95% CI: 0.10-0.48). Incident loneliness at age 14 showed similar associations. No association was found for adolescents whose loneliness had remitted by age 14 (RD -1.3%, 95% CI: -3.6 to 1.2; RR 0.73, 95% CI: 0.31-1.26; β 0.01, 95% CI: -0.04 to 0.08). Sensitivity analyses using marginal structural models yielded results that were largely unchanged. Findings were generally similar for other mental health problems. Associations were consistent across genders, although the association with well-being appeared particularly important for girls.

conclusionsThe dynamics of loneliness are associated with a wide range of mental health problems in adolescents. The risk may not be permanent and could be mitigated if loneliness remits. Further research examining interventions that target loneliness is warranted.

Indexed as

AnxietyDepressionLonelinessPsychotic DisordersAdolescentChildFemaleHumansLongitudinal StudiesMalePsychological Well-BeingTokyoadolescenceanxietyMajor depressive disorder (MDD)psychosisschizophrenia

Identifiers

PMID41567036
PMCPMC7619271

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.