Evidence map›Paper›PMID 41566994›Full record

ArticleUltrasonography (Seoul, Korea)2026

Direct deep learning analysis of three-dimensional automated breast ultrasound videos with reading mode optimization for breast cancer diagnosis.

Yuqing Guo, Changyan Wang, Yingchun Liu, Yun Pang, Rui Ge, Weiping Li, Lizhuang Liu, Qi Zhang, Lin Chen

Abstract read
In one paragraph

Article in Ultrasonography (Seoul, Korea), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuqing GuoDepartment of Ultrasound, Huadong Hospital, Fudan University, Shanghai, China.
Changyan WangSchool of Communication and Information Engineering, Shanghai University, Shanghai, China.
Yingchun LiuDepartment of Ultrasound, Huadong Hospital, Fudan University, Shanghai, China.
Yun PangDepartment of Ultrasound, Huadong Hospital, Fudan University, Shanghai, China.
Rui GeDepartment of Surgery, Huadong Hospital, Fudan University, Shanghai, China.
Weiping LiDepartment of Surgery, Huadong Hospital, Fudan University, Shanghai, China.
Lizhuang LiuShanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China.
Qi ZhangSchool of Communication and Information Engineering, Shanghai University, Shanghai, China.
Lin ChenDepartment of Ultrasound, Huadong Hospital, Fudan University, Shanghai, China.

Funding

2020 National Natural Science Foundation of China Project 620712852022 Science and Technology Project from the Technology Innovation Action Plan 22Y11911600
6 · The paper itself

Abstract

purposeThis study aimed to develop and evaluate a deep learning model that directly analyzes three-dimensional automated breast ultrasound videos (DL-3DABUV) to assist breast cancer diagnosis, and to examine the optimal reading mode for clinical implementation.

methodsThis retrospective study included 547 patients (285 benign, 262 malignant), who were randomly assigned to a training set (n=437) and a test set (n=110). The DL-3DABUV model, built using ResNet50 and multi-instance learning, was trained by directly analyzing videos without image selection or manual annotation. Six radiologists (three experienced and three novice) evaluated the test set under three modes: independent-reading (without DL-3DABUV), second-reading (without prior knowledge of DL-3DABUV results), and concurrent-reading (after viewing DL-3DABUV results). The diagnostic performance of DL-3DABUV, experienced radiologists, and novice radiologists was compared. Reading times across the three modes were also assessed.

resultsCompared to experienced radiologists in independent reading, DL-3DABUV showed no significant differences in area under the receiver operating characteristic curve (AUC) (0.82 vs. 0.83), sensitivity (82.1% vs. 81.6%), or specificity (81.5% vs. 88.3%) (all P>0.05). DL-3DABUV exhibited higher AUC and specificity than novice radiologists in independent-reading (0.82 vs. 0.68, P<0.001; 81.5% vs. 57.4%, P<0.001). However, novice performance reached parity with DL-3DABUV in both second-reading and concurrent-reading. No significant differences in diagnostic performance were observed between second-reading and concurrent-reading. Concurrent reading significantly reduced reading time by 33.6 seconds compared with second-reading (P<0.001).

conclusionDL-3DABUV achieves diagnostic performance comparable to experienced radiologists and enhances diagnostic accuracy for novices. Concurrent reading provides a more efficient workflow by reducing reading time while maintaining diagnostic performance.

Indexed as

Automated breast ultrasoundBreast neoplasmsDeep learningReading mode

Identifiers

PMID41566994
PMCPMC12856069

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.