ArticleClinical and experimental pediatrics2026
Can a basophil activation test of cord blood predict a cow's milk allergy?
Article in Clinical and experimental pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFood allergies affect 4%-6% of the pediatric population and are often present within the first 2 years of life. Cord blood cells and cytokines in high-risk infants can predict allergic problems; however, their predictive value remains unclear. PURPOSE: This study aimed to determine whether a cow's milk allergy in infants can be predicted using a basophil activation test (BAT) of cord blood samples by stimulating basophils with milk protein antigens (cow's milk and casein).
methodsWe collected cord blood during the birth of 30 mother-child pairs and immediately analyzed BAT stimulated with milk protein antigens. One year later, we compared the results of those infants who developed an allergy to those who did not.
resultsWe found that infants with a casein-BAT value ≥2.6 were 33.2 times more likely than those with a casein- BAT value <2.6 to develop food allergy symptoms within the first year of life (P=0.03).
conclusionHigh casein-BAT values in cord blood may predict the development of food allergies during the first year of life. Although no association with cow's milk sensitivity has been found, casein sensitivity may indicate food allergy risk. However, further studies are required to confirm this association.
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