Evidence map›Paper›PMID 41566958›Full record

ArticleBiomaterials science2026

Dynamic granular hydrogels to assess pancreatic cancer cell fate.

Ellen Frahm, Chien-Chi Lin

Abstract read
In one paragraph

Article in Biomaterials science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ellen FrahmWeldon School of Biomedical Engineering, Purdue University, 206 Martin Jischke Dr, West Lafayette, IN, 47907, USA.
Chien-Chi LinWeldon School of Biomedical Engineering, Purdue University, 206 Martin Jischke Dr, West Lafayette, IN, 47907, USA.ORCID http://orcid.org/0000-0002-4175-8796

Funding

BRAVE hydrogels for interrogating cell-matrix interactions in pancreatic desmoplasia: Admin SuppR01CA227737 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI LIN, CHIEN-CHI · 2019 to 2022
$1.5M
NCI NIH HHS R01 CA227737
6 · The paper itself

Abstract

Granular hydrogels are an emerging biomaterial platform increasingly used in biomedical applications, including therapeutic delivery and tissue regeneration. Assembled from micron-scale hydrogel particles through physical assembly or chemical cross-linking, granular hydrogels possess micro- and macroscopic pores that facilitate molecular transport and cell migration. However, current granular hydrogels are typically fabricated with defined stiffness, porosity, and compositions that do not recapitulate the dynamic nature of native tissues, including the tumor microenvironment. To address this challenge, we have developed dynamic granular hydrogels formed by gelatin-norbornene-carbohydrazide (GelNB-CH) microgels. GelNB-CH microgels were first prepared from a microfluidic droplet generator coupled with the rapid thiol-norbornene photo-click gelation. The collected microgels were annealed

Indexed as

Biocompatible MaterialsHydrogelsPancreatic NeoplasmsCell Line, TumorCell MovementGelatinHumansHydrazinesNorbornanesTumor Microenvironment2-norborneneBiocompatible MaterialsGelatinHydrazinesHydrogelsNorbornanes

Identifiers

PMID41566958
PMCPMC12824579

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.