SynthesisEnvironmental toxicology2026
Revisiting the Association of Pesticide Exposure and Parkinson's Disease: Systematic Review and Meta-Analysis.
Synthesis in Environmental toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- von Willebrand Factor fibers formed at pathological high shear provide a scaffold for α-synuclein binding and aggregation.Scientific reports · 2026Article
- Dose-response toxicity and locomotor effects ofFrontiers in toxicology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between pesticide exposure and Parkinson's disease (PD) is substantial, but heterogeneity in methodology and lack of categorization according to the type of exposure and pesticide classes in previous meta-analyses impair the interpretation of data. This study aims to update evidence of the association between pesticide exposure and PD. We conducted a systematic review and meta-analysis of studies investigating associations between pesticide exposure and PD according to the type of pesticide exposure and pesticide class. We searched PubMed, EMBASE, and Web of Science until July 2024. Reviewers screened titles and abstracts. Afterward, reviewers reanalyzed the selection criteria and extracted the data based on the full paper. Meta-analyses were conducted to assess the association between pesticide exposure and PD. A total of 124 studies were eligible. There is a lack of diversity in the populations represented and a high variability in methodology among the included studies. Considering only studies with any type of exposure, we found a positive association of PD with any pesticide class and herbicides. Occupational exposure was associated with PD for all pesticide classes except for fungicides. Exclusive household pesticide exposure was also associated with PD. Pesticide exposure remains a significant environmental risk factor for the development of PD, regardless of the type of exposure. Herbicides are the pesticide class with the most substantial evidence of association with the disease. Further studies with new methods of pesticide exposure measurement, innovative design studies, and the inclusion of underrepresented populations are still needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.