Evidence map›Paper›PMID 41566543›Full record

ReviewSkeletal muscle2026

The contribution of skeletal muscle interstitial cells to myogenesis.

Fayez Issa, Frédéric Relaix, Joana Esteves de Lima

Abstract readReview
In one paragraph

Review in Skeletal muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fayez IssaUniv Paris-Est Créteil, INSERM, U955 IMRB, F-94010, Créteil, France.
Frédéric RelaixUniv Paris-Est Créteil, INSERM, U955 IMRB, F-94010, Créteil, France. frederic.relaix@inserm.fr.
Joana Esteves de LimaUniv Paris-Est Créteil, INSERM, U955 IMRB, F-94010, Créteil, France. joana.esteves-de-lima@inserm.fr.

Funding

Agence Nationale de la Recherche ANR-22-CE13-0003-01
6 · The paper itself

Abstract

The developmental origin of skeletal muscle cell lineages has been extensively studied in the last 50 years. PAX3 + /PAX7 + myogenic progenitors are the foundation for skeletal muscle development and give rise to muscle satellite cells that support skeletal muscle postnatal growth, homeostasis and regeneration. Research into muscle connective tissue interstitial cells established their supportive role in muscle patterning during development and regeneration. With recent advances in mouse genetic lineage tracing, single cell transcriptomics and specific antibodies, the origin and the contribution of non-myogenic interstitial populations to the myogenic lineage have been reexamined. Growing evidence suggests that subpopulations of muscle interstitial cells actively contribute to myogenesis and fuse with myofibers during development, postnatal growth, and regeneration. In this review, we focus on the recent research advances that highlighted the direct contribution of interstitial cells, particularly connective tissue cells, to skeletal muscle growth and repair. We stress the importance of further investigating the mechanisms by which interstitial cells contribute to a myogenic fate in both physiological and pathological conditions.

Indexed as

Muscle DevelopmentMuscle, SkeletalAnimalsCell DifferentiationCell LineageHumansRegenerationSatellite Cells, Skeletal MuscleConnective tissueDevelopmentFAPsMyogenesisRegeneration

Identifiers

PMID41566543
PMCPMC12952177

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.