Evidence map›Paper›PMID 41566433›Full record

ArticleBMC genomics2026

Sperm RNA landscape during sexual maturation in Duroc boars.

Asmita Shrestha, Maren van Son, Adnan Hashim, Soudabeh Rouzbehani, Gregor D Gilfillan, Urszula Berge, Elisabeth Kommisrud, Anne Hege Alm-Kristiansen

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In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Asmita ShresthaCRESCO, Centre for Embryology and Healthy Development, University of Inland Norway, Hamar, Norway. asmita.shrestha@inn.no.
Maren van SonNorsvin SA, Hamar, Norway.
Adnan HashimCRESCO, Centre for Embryology and Healthy Development, University of Oslo, Oslo, Norway.
Soudabeh RouzbehaniCRESCO, Centre for Embryology and Healthy Development, University of Inland Norway, Hamar, Norway.
Gregor D GilfillanDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Urszula BergeDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Elisabeth KommisrudCRESCO, Centre for Embryology and Healthy Development, University of Inland Norway, Hamar, Norway.
Anne Hege Alm-KristiansenCRESCO, Centre for Embryology and Healthy Development, University of Inland Norway, Hamar, Norway. anne.almkristiansen@inn.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSexual maturation in boars impacts reproductive efficiency in swine production, yet the molecular mechanisms underlying this developmental transition remain poorly understood. This study aimed to investigate the transcriptomic changes in sperm from Duroc boars during sexual maturation, conducting a longitudinal analysis. The total RNA and miRNA profiles from the same individuals (n = 6) at puberty (7.24 ± 0.39 months) and sexual maturity (10 ± 0.40 months) were compared, identifying molecular signatures associated with reproductive development. Total RNA sequencing (Illumina NovaSeq-6000) and miRNA sequencing (Illumina NextSeq-500) were performed on all 12 paired samples (6 boars at 2 time points), followed by differential expression analysis using a paired statistical model in DESeq2 to account for repeated measures.

resultsDifferential expression analysis identified 60 differentially expressed genes using stringent criteria (adj P < 0.05, |log

conclusionsOur study reveals coordinated transcriptomic shifts in boar sperm during sexual maturation. Most genes show increased RNA abundance at 10 months of age, with enrichment in terms of reproductive development. Several miRNAs appear to regulate these changes through targeted mRNA interactions. These findings expand our understanding of the biological processes underlying sexual maturation in pigs.

Indexed as

RNASexual MaturationSpermatozoaAnimalsGene Expression ProfilingGene Expression Regulation, DevelopmentalMaleMicroRNAsSwineTranscriptomeMicroRNAsRNAmiRNAPorcine spermatozoaPubertySexual maturation

Identifiers

PMID41566433
PMCPMC12906034

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.