ArticleJournal of translational medicine2026
Single-cell transcriptome analysis reveals mechanisms by which hippocampal deep brain stimulation promotes neurorepair and microglial subpopulation remodeling in ischemic stroke.
Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIn patients with ischemic stroke, the hippocampus is one of the most severely damaged regions of the brain; however, the optimal parameters for hippocampal deep brain stimulation in these patients remain unknown. The underlying mechanism of hippocampal deep brain stimulation in the treatment of ischemic stroke is not fully understood.
objectiveTo investigate the effect and underlying mechanisms by which hippocampal deep brain stimulation enhances the repair of brain damage from ischemic stroke.
methodsWe utilized multi-channel electrode arrays to record local field potentials and to monitor motor symptoms in mice with ischemic stroke during deep brain stimulation in hippocampus. Using 10x single-cell transcriptome sequencing and RNA-seq in stroke mice with and without electrostimulation treatment, we explored the underlying mechanisms.
resultsAfter being treated with hippocampal deep brain stimulation, the stroke mice showed significant improvements in motor ability, neuronal function, and behaviors related to anxiety/depression. Bioinformatics analysis and subsequent investigations revealed a significant increase in the quantity of excitatory neurons and astrocytes in the hippocampus following deep brain stimulation while the number of oligodendrocytes, microglia and inhibitory neurons was markedly diminished. The microglia subset 5 showed a significant increase following deep brain stimulation treatment, while subsets 3 and 4 experienced a significant reduction. Within subset 5, markers such as Cd93, Ccr2, Emilin2, Pirb, Lgals3, Thbs1, Gpnmb, and Ccr1 were associated with immune inflammation and angiogenesis.
conclusionCollectively, our findings imply that hippocampal deep brain stimulation is highly effective for treating ischemic stroke and offer deeper insights into the potential mechanisms by which hippocampal deep brain stimulation improves stroke symptoms. These findings support hippocampal deep brain stimulation as a promising novel therapeutic approach for stroke and offer valuable insights for the treatment of other neurological disorders.
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