Evidence map›Paper›PMID 41566356›Full record

ArticleHereditas2026

Genetic polymorphism of long non-coding RNA TUG1 and susceptibility to polycystic ovary syndrome: a case-control study.

Hua Zhang, Wei Liu, Xueqian Liu, Jingjing Ren, Yijiao Cheng, Yanjiao Liu, Yanjun Wu

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Article in Hereditas, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Hua Zhang *Department of Obstetrics and Gynecology, Liaocheng People's Hospital, No.67 Dongchang West Road, Liaocheng, 252000, China.
Wei Liu *Department of Obstetrics, Shenzhen Futian District Maternal and Child Health Hospital, Shenzhen, 518000, China.
Xueqian LiuObstetrical Department, Affiliated Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing, 100020, China. liuxueqian0222@163.com.
Jingjing RenObstetrical Department, Affiliated Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing, 100020, China.
Yijiao ChengObstetrical Department, Affiliated Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing, 100020, China.
Yanjiao LiuObstetrical Department, Affiliated Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing, 100020, China.
Yanjun WuDepartment of Obstetrics and Gynecology, Liaocheng People's Hospital, No.67 Dongchang West Road, Liaocheng, 252000, China. wuyanjunlc@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDysregulated expression of long non-coding RNA (lncRNA) TUG1 participates in the etiopathogenesis of polycystic ovary syndrome (PCOS). This study analyzed the genetic association of the TUG1 rs5749201 polymorphism in PCOS patients.

methodsGenotype and allele distributions of rs5749201 were analyzed in 210 PCOS patients and 230 healthy volunteers. Serum TUG1 levels were detected via qRT-PCR. The relationship between gene polymorphism and PCOS risk was analyzed via multivariate logistic regression.

resultsCompared with the control group, the PCOS group had a significantly higher proportion of carriers with TUG1 rs5749201 AA genotype and a lower proportion of TT genotype carriers. Rs5749201 TT genotype carriers had notably reduced PCOS risk. This genetic association was also found in dominant and recessive models, with the locus independently linked to PCOS (OR = 0.427, 95%CI: 0.242-0.753; P = 0.003). AA genotype carriers had higher LDL, TG and FBS than AT/TT genotype carriers. PCOS patients had elevated TUG1 levels, with AA genotype carriers showing the highest.

conclusionTUG1 rs5749201 was linked to PCOS susceptibility, which is correlated with its regulatory role in TUG1 expression.

Indexed as

Genetic Predisposition to DiseasePolycystic Ovary SyndromePolymorphism, Single NucleotideRNA, Long NoncodingAdultAllelesCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenotypeHumansRNA, Long NoncodingTUG1 long noncoding RNA, humanGenetic predispositionPolycystic ovary syndromeSNPTUG1

Identifiers

PMID41566356
PMCPMC12911283

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.