Evidence map›Paper›PMID 41566216›Full record

ArticleBMC genomics2026

Circ_0008219 regulates proliferation and apoptosis in goat granulosa cells via a feedback loop with the transcription factor YY1.

Hu Tao, Fan Jiang, Nian Zhang, Yi Shuai, Hua Zhao, Juan Yang, Feng Zhang, Aishao Shangguan, Qi Xiong

Abstract read
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In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hu TaoHubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, No.1 Nanhu Yaoyuan, South Lack Road, Hongshan District Wuhan, Wuhan, 430064, China.
Fan JiangHubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, No.1 Nanhu Yaoyuan, South Lack Road, Hongshan District Wuhan, Wuhan, 430064, China.
Nian ZhangHubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, No.1 Nanhu Yaoyuan, South Lack Road, Hongshan District Wuhan, Wuhan, 430064, China.
Yi ShuaiSchool of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, 621010, China.
Hua ZhaoSchool of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, 621010, China.
Juan YangHubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, No.1 Nanhu Yaoyuan, South Lack Road, Hongshan District Wuhan, Wuhan, 430064, China.
Feng ZhangHubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, No.1 Nanhu Yaoyuan, South Lack Road, Hongshan District Wuhan, Wuhan, 430064, China.
Aishao ShangguanHubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, No.1 Nanhu Yaoyuan, South Lack Road, Hongshan District Wuhan, Wuhan, 430064, China.
Qi XiongHubei Key Laboratory of Animal Embryo Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, No.1 Nanhu Yaoyuan, South Lack Road, Hongshan District Wuhan, Wuhan, 430064, China. phenixxq@163.com.

Funding

Funds for Supporting High-Quality Development of Seed and Breeding Industry Projects in Hubei Province HBZY2023B008Hubei Provincial Technology Innovation Plan Project 2024BBB112JD Technology Research and Development Project of Hubei Province 2023BAA029National Natural Science Foundation of China 31972995
6 · The paper itself

Abstract

backgroundCircular RNAs (circRNAs) are a class of competitive endogenous RNAs (ceRNAs) widely found in animals, they can directly or indirectly affect the proliferation and apoptosis of granulosa cells (GCs) by regulating microRNA (miRNA) pathways. Preliminary research findings indicate that circ_0008219 is differentially expressed in pre-ovulatory follicles between Boer goats and Macheng black goats, suggesting its potential critical role in goat ovulation. As a potential target, its specific functions and regulatory mechanisms warrant further investigation.

resultsA feedback loop of the YY1/circ_0008219/miR-130b-5p/FZD7 axis was constructed to elucidate the function and regulatory mechanism of circ_0008219 promoting GCs proliferation and suppressing apoptosis. Subsequent validation experiments were conducted in vitro using GCs. In our experiments, we identified circ_0008219 as a ceRNA in goat GCs that promoted proliferation. Through bioinformatics prediction and dual-luciferase reporter assays, we confirmed that circ_0008219 acts as a sponge for miR-130b-5p, preventing its binding to FZD7 mRNA and thereby increasing the expression of FZD7. This interaction also influenced the proliferation and apoptosis of goat GCs. Moreover, the transcription factor YY1 was found to form a feedback loop with circ_0008219 via the linkage of miR-130b-5p.

conclusionsOur study validated the biological function of the TF-circRNA-miRNA-mRNA feedback loop in goat GCs and revealed the potential regulatory mechanism by which circ_0008219 functions as a ceRNA in goat GCs, thus provide new insights into the mechanisms of regulated ovarian follicles development in female goats.

Indexed as

ApoptosisGranulosa CellsRNA, CircularYY1 Transcription FactorAnimalsCell ProliferationFeedback, PhysiologicalFemaleGene Expression RegulationGoatsMicroRNAsRNA, Competitive EndogenousMicroRNAsRNA, CircularRNA, Competitive EndogenousYY1 Transcription FactorApoptosisCirc_0008219GoatGranulosa cellsProliferation

Identifiers

PMID41566216
PMCPMC12908286

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.