Evidence map›Paper›PMID 41566099›Full record

ArticleEJNMMI research2026

Prediction of tumour hypoxia status from the washout of positron emitters in beam-monitoring PET: carbon-ion irradiation to tumour rat models.

Chie Toramatsu, Hidekatsu Wakizaka, Hideaki Tashima, Hitomi Sudo, Go Akamatsu, Taiyo Ishikawa, Han Gyu Kang, Chie Seki, Iwao Kanno, Taiga Yamaya

Abstract read
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In one paragraph

Article in EJNMMI research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Chie ToramatsuNational Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan. toramatsu.chie@qst.go.jp.ORCID http://orcid.org/0000-0003-2334-1986
Hidekatsu WakizakaNational Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.
Hideaki TashimaNational Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.
Hitomi SudoNational Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.
Go AkamatsuNational Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.
Taiyo IshikawaNational Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.
Han Gyu KangNational Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.
Chie SekiNational Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.
Iwao KannoNational Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.
Taiga YamayaNational Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.

Funding

Japan Society for the Promotion of Science London 23KK0206Japan Society for the Promotion of Science London 24K10826
6 · The paper itself

Abstract

backgroundThe aim of this study was to identify hypoxic regions in tumours using non-invasive imaging without specific radioligands. Tumour hypoxia, which varies during the course of radiation therapy, is an important predictor of treatment effect, therefore, frequent monitoring is required. However, positron emission tomography (PET) using hypoxia-specific radioligands is impractical to perform in every fractionated irradiation. Alternatively, blood flow can be evaluated by measuring washout rates of irradiation-induced positron-emitters in range-verification or beam-monitoring PET. Based on this, we hypothesized that the blood flow supply and kinetics (washout) of the irradiation-produced positron-emitters in the tumour could reflect the tumour oxygen status. Beam-monitoring PET for hypoxic tumour rat models was compared with conventional hypoxia PET. Glioma C6 cancer cells were transplanted into nude rats. Tumours were irradiated with a 12C ion beam, and beam-monitoring PET was performed using a high sensitivity total-body small-animal PET system. A compartment model was applied to the kinetic data of the irradiation produced positron-emitters. Then, 18F-labeled fluoroazomycin arabinoside (18F-FAZA) PET imaging of the hypoxia area of the tumour of the same rat was performed.

resultsThe parametric images of washout rate obtained with beam-monitoring PET were in good agreement with 18F-FAZA-PET images.

conclusionThis study demonstrated the biological washout can be used as diagnostic tool for tumour hypoxia in routine beam-monitoring PET.

Indexed as

AngiogenesisBlood flowHypoxiaParticle therapyTumour

Identifiers

PMID41566099
PMCPMC12909694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.