ArticleCommunications chemistry2026
Sequence and length-scale dependent dynamics in biocondensates of highly charged disordered proteins.
Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Highly-charged intrinsically disordered proteins (IDPs) underpin biomolecular condensate formation through liquid-liquid phase separation, yet the influence of charge sequences on the dynamics within the condensate phase remains poorly understood. Using extensive molecular dynamics simulations with explicit hydrodynamics and electrostatics, we study the dynamics in IDP condensates across different length and time scales, by systematically varying the charge sequences of the constituent IDPs. Contrary to the expectation that long-range interactions are heavily screened in dense semidilute polymer solutions, we find hydrodynamics and electrostatics significantly influence the dynamics in IDP condensates and their effects are strongly coupled to the charge sequence of the constituent IDPs. For condensates of low to intermediate-κ IDPs, where κ is a measure of the charge blockiness of the charge sequence, we find hydrodynamics dominates the dynamics up to the length scale of the chain and beyond. On the sub-chain level, segmental relaxation is highly coupled to intra-chain electrostatic correlations due to local charge patterns, where sections with more charge-balanced blocks have faster relaxation. Furthermore, the viscosity in IDP condensates is significantly length-scale-dependent, with condensates of high-κ IDPs exhibiting large difference between microscopic and macroscopic viscosity. Such length-scale-dependent viscosity may be the key to understanding the experimentally observed extremely fast molecule-level dynamics in biocondensates of highly-charged IDPs. Our findings highlight the intricate relationship between charge sequences, hydrodynamics, and electrostatics in shaping the dynamics in IDP condensates at different length and time scales.
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