Evidence map›Paper›PMID 41565931›Full record

ArticleCommunications biology2026

Development of a novel humanized gut-brain axis model as a tool toward personalized nutrition.

Myrto S Chatzopoulou, Ravi Vumma, Samira Prado, Mathias W Scharf, Victor Castro-Alves, Ashley N Hutchinson, Ignacio Rangel, Tatiana M Marques, Rebecca Wall, Robert J Brummer and 1 more

Abstract read
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Myrto S ChatzopoulouSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden.ORCID http://orcid.org/0000-0002-0117-9052
Ravi VummaDepartment of Chemistry and Biomedical Sciences, Linnaeus University, 39231, Kalmar, Sweden.ORCID http://orcid.org/0000-0001-8834-8383
Samira PradoSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden.ORCID http://orcid.org/0000-0003-4627-6291
Mathias W ScharfSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden.ORCID http://orcid.org/0000-0002-4783-7399
Victor Castro-AlvesSchool of Science and Technology, Faculty of Science, Business and Engineering, Örebro University, 70182, Örebro, Sweden.ORCID http://orcid.org/0000-0002-9535-6821
Ashley N HutchinsonSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden.
Ignacio RangelSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden.
Tatiana M MarquesSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden.
Rebecca WallSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden.
Robert J BrummerSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden.ORCID http://orcid.org/0000-0002-0362-0008
Julia RodeSchool of Medical Sciences, Faculty of Medicine and Health, Örebro University, 70182, Örebro, Sweden. Julia.rode@oru.se.ORCID http://orcid.org/0000-0001-9402-4756

Funding

European Society for Clinical Nutrition and Metabolism (ESPEN) Research Fellowship 2020Vetenskapsrådet (Swedish Research Council) 2017-02694
6 · The paper itself

Abstract

Intestinal luminal microbial metabolites affect tryptophan and serotonin metabolism, and cross or modify the blood-brain barrier (BBB). Understanding those mechanisms further necessitates integrated gut-brain axis model systems. Using an ex vivo-in vitro approach, H

Indexed as

Blood-Brain BarrierBrain-Gut AxisPrecision MedicineCells, CulturedColonFibroblastsHumansHydrogen PeroxideIrritable Bowel SyndromeModels, BiologicalOxidative StressHydrogen Peroxide

Identifiers

PMID41565931
PMCPMC12824285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.