Evidence map›Paper›PMID 41565900›Full record

ArticleJournal of robotic surgery2026

Robotic assisted radical prostatectomy improves biochemical recurrence-free survival: The PROCA-life study.

Tore Knutsen, Erling Aarsaether, Tom Wilsgaard, Martin Støyten, Einar Stikbakke, Elin Richardsen, Magnus Larsen, Inger Thune, Hege Sagstuen Haugnes

Abstract read
In one paragraph

Article in Journal of robotic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tore KnutsenInstitute of Clinical Medicine, UIT- The Arctic University, 9037, Tromsø, Norway.
Erling AarsaetherInstitute of Clinical Medicine, UIT- The Arctic University, 9037, Tromsø, Norway.
Tom WilsgaardInstitute of Community Medicine, UIT- The Arctic University, 9037, Tromsø, Norway.
Martin StøytenInstitute of Clinical Medicine, UIT- The Arctic University, 9037, Tromsø, Norway.
Einar StikbakkeInstitute of Clinical Medicine, UIT- The Arctic University, 9037, Tromsø, Norway.
Elin RichardsenDepartment of Pathology, University Hospital of North Norway, 9038, Tromsø, Norway.
Magnus LarsenInstitute of Clinical Medicine, UIT- The Arctic University, 9037, Tromsø, Norway.
Inger ThuneInstitute of Clinical Medicine, UIT- The Arctic University, 9037, Tromsø, Norway.
Hege Sagstuen HaugnesInstitute of Clinical Medicine, UIT- The Arctic University, 9037, Tromsø, Norway. hege.sagstuen.haugnes@uit.no.ORCID http://orcid.org/0000-0002-9813-0561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Robotic-assisted laparoscopic prostatectomy (RALP) is the preferred surgical technique compared to radical retropubic prostatectomy (RRP), but reports have been inconsistent on the effect of RALP on positive surgical margins (PSM) and biochemical recurrence (BCR). This study includes 420 men who participated in the population-based Tromsø study and PROCA-life study, diagnosed with prostate cancer (PCa) during 1995–2022, and treated with curative surgery. Overall, 171 PCa patients underwent open surgery with RRP, performed 1995–2012, and 249 PCa patients underwent RALP, performed 2012–2022. Preoperative and postoperative clinical characteristics were recorded. Multivariable Cox regression models presented with hazard ratios (HR) were used to study the association between surgical technique, preoperative and postoperative characteristics, and BCR. Overall, 72 patients (42.1%) in the RRP group, and 47 patients (18.9%) in the RALP group had BCR. Median time from surgery to BCR was 26.9 (IQR 10.2–58.0) months and 24.5 (IQR 15.4–46.9) months, respectively. PSM were three times more frequent in the RRP group compared to the RALP group (42.9% vs. 14.0%). Five-year BCR-free survival in the RRP group was 67% (95% CI 59–74), in the RALP group 81% (95% CI 75–86). The RALP procedure independently decreased the risk of BCR compared to RRP (HR 0.52; 95% CI 0.34–0.80, p = 0.003). PCa patients who had PSM had a doubled risk of BCR compared with patients with negative surgical margins (HR 2.00; 95% CI 1.31–3.05, p < 0.001). Patients with ISUP grade 3–5 (vs. grade 1) had an increased risk of BCR, highest with ISUP 4/5 (HR 3.44, 95% CI 1.79–6.61, p < 0.001). Implementation of RALP reduced the risk of biochemical recurrence compared to RRP, partly explained by the markedly lower PSM rate after RALP.

Indexed as

LaparoscopyProstatectomyProstatic NeoplasmsRobotic Surgical ProceduresAgedDisease-Free SurvivalHumansMaleMargins of ExcisionMiddle AgedNeoplasm Recurrence, LocalProstate-Specific AntigenProstate-Specific AntigenProstate cancerProstatectomyRecurrenceSurgical margins

Identifiers

PMID41565900
PMCPMC12823714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.