Evidence map›Paper›PMID 41565805›Full record

ArticleNature2026

Common variation in meiosis genes shapes human recombination and aneuploidy.

Sara A Carioscia, Arjun Biddanda, Margaret R Starostik, Xiaona Tang, Eva R Hoffmann, Zachary P Demko, Rajiv C McCoy

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sara A Carioscia *Department of Biology, Johns Hopkins University, Baltimore, MD, USA.
Arjun Biddanda *Department of Biology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-1861-1523
Margaret R StarostikDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-5274-2765
Xiaona TangDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-2665-1197
Eva R HoffmannDepartment of Cellular and Molecular Medicine, DNRF Center for Chromosome Stability, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2588-0652
Zachary P DemkoNatera Inc., San Carlos, CA, USA.ORCID 0000-0001-8796-2381
Rajiv C McCoyDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA. rajiv.mccoy@jhu.edu.ORCID 0000-0003-0615-146X

Funding

Kinetic Mechanisms of Chromatin Remodeling and TranscriptionR35GM149291 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Carl Wu · 2023 to 2026
$3.6M
Function and fitness consequences of human genetic variationR35GM133747 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Rajiv Champion McCoy · 2019 to 2026
$3.3M
National Science Foundation Graduate Research FellowshipNIGMS NIH HHS R35 GM133747NIGMS NIH HHS R35 GM149291
6 · The paper itself

Abstract

The leading cause of human pregnancy loss is aneuploidy, often tracing to errors in chromosome segregation during female meiosis

Indexed as

AneuploidyCrossing Over, GeneticGenetic VariationMeiosisRecombination, GeneticCell Cycle ProteinsChromosomal Proteins, Non-HistoneChromosome SegregationCohesinsFemaleFertilization in VitroHaplotypesHumansMalePregnancyPreimplantation DiagnosisCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsUbiquitin-Protein Ligases

Identifiers

PMID41565805
PMCPMC12960220

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.