ArticleNature communications2026
Impact and cost-effectiveness of doxycycline post-exposure prophylaxis in Australian men who have sex with men.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Mechanisms, management and prevention of anorectal sexually transmitted infections.Nature reviews. Gastroenterology & hepatology · 2026Review
- Impact and cost-effectiveness of doxycycline post-exposure prophylaxis in Australian men who have sex with men.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The optimal implementation of doxycycline post-exposure prophylaxis (doxy-PEP) for preventing bacterial sexually transmitted infections (STIs) among Australian men who have sex with men is unclear due to concerns about antimicrobial resistance and cost-effectiveness. We developed an individual-based model, calibrated to Australian national data, to compare five targeted doxy-PEP strategies with a base case from 2025 to 2034, using a multi-criteria ranking framework to evaluate their epidemiological, resistance, and economic outcomes. All evaluated strategies reduced STIs by 13.0% to 47.8% and were cost-saving. However, compared to the high 73.5% baseline projection for high-level tetracycline resistance by 2034, all strategies yielded higher proportions. This proportion was highest (97.4%) when targeting all HIV pre-exposure prophylaxis users, and lowest (81.2%) for the syphilis diagnosis strategy. This syphilis-focused strategy reduced overall STIs by 16.4%, had the highest benefit-cost ratio (9.2), and ranked highest in 9 of 11 evaluation frameworks. Here, we show that doxy-PEP is an effective, cost-saving intervention, with the syphilis diagnosis strategy representing the most recommended approach to optimally balance benefits and risks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.