ArticleNature communications2026
A Glial Hub-and-Spoke Circuitry in C. elegans orchestrates bidirectional thermosensation.
Linhui Zhu, Rong Li, Mengyi Qian, Fangjin Lv, Huitao Hong, Yumeng Li, Yongqi Zhou, Zhou Li, Jing Lei, Wenjuan Zou and 6 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
Linhui Zhu *College of Life Science and Technology, Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology, Wuhan, China.
Mengyi QianDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.ORCID http://orcid.org/0009-0001-9124-6043 Fangjin LvDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.
Huitao HongDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.
Yumeng LiDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.
Yongqi ZhouDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.
Zhou LiDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.
Jing LeiDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.
Wenjuan ZouDepartment of Neurosurgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yongming ZhangDepartment of Ophthalmology of the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.
Guohua ZhaoDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.ORCID http://orcid.org/0000-0003-0593-9175 Huan MaLiangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0003-4359-8631 Lijun KangDepartment of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China. kanglijun@zju.edu.cn.ORCID http://orcid.org/0000-0001-9939-5134 Funding
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MMinistry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021ZD0203303National Foundation of Natural Science of ChinaNIH HHS P40 OD010440
6 · The paper itselfAbstract
Thermosensation is evolutionarily conserved for survival, yet the roles of glia in temperature coding and circuit dynamics remain poorly understood. Here, we identify C. elegans AMsh glia as dual-mode thermosensory hubs that autonomously detect temperature fluctuations by co-expressing the heat receptor GCY-28 (guanylate cyclase) and cold receptor GLR-3 (ionotropic glutamate receptor). Thermal changes induce spatiotemporal calcium dynamics in glia, driving GABA release to bidirectionally modulate neural circuits: enhancing AFD-mediated warmth detection through the excitatory receptor EXP-1 and suppressing ASH-dependent cold avoidance via the inhibitory receptor LGC-38. This GABAergic hub-and-spoke architecture regulates a broad range of thermal behaviors, including thermal avoidance, thermal resistance, and thermal preference. These findings establish glia as critical interpreters of environmental cues, highlighting their dual roles as sensors and modulators in sensory processing and providing a paradigm for understanding conserved glial mechanisms in neural circuit dynamics and behavioral plasticity.
Indexed as
Caenorhabditis elegansNeurogliaThermosensingAnimalsAnimals, Genetically ModifiedCaenorhabditis elegans ProteinsCalciumgamma-Aminobutyric AcidGuanylate CyclaseCaenorhabditis elegans ProteinsCalciumgamma-Aminobutyric AcidGuanylate Cyclase
Identifiers
PMID41565681
PMCPMC12923798
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