ArticleNature communications2026
A fully degradable triboelectric vagus nerve stimulator for attenuating cardiac remodeling and heart failure at different stages.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Engineering trustworthy closed-loop bioelectronic systems for cardiovascular disease.Innovation (Cambridge (Mass.)) · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
Heart failure affects approximately 56 million people worldwide with a 5-year mortality rate exceeding 50%, necessitating new therapeutic strategies. Although low-level vagus nerve stimulation shows promise for treating heart failure, existing devices are limited by short battery life, lack of degradability, and insufficient adaptability to disease progression. Here we develop a fully biodegradable triboelectric nanogenerator for self-powered vagus nerve stimulation that prevents and reverses myocardial remodeling through acetylcholine release modulation. In a murine heart failure model, the device generates 9.07 ± 0.43 V open-circuit voltage and 4.19 ± 0.14 μA short-circuit current, enabling stable stimulation for 4 weeks with rapid ultrasound-triggered degradation. We show that device-based vagus nerve stimulation significantly improves cardiac function, attenuates pathological remodeling, and favorably modulates heart failure-related gene expression across multiple disease stages. This technology eliminates battery replacement surgeries and device removal procedures, establishing a paradigm for personalized, stage-specific heart failure therapy.
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Registered trials
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